This test is useful in cases of hematological maligancies with a suspected BCR/ABL Translocation. In such cases, a larger segment of a proto-oncogene, called ABL, on chromosome 9 is translocated to the BCR gene which is present on chromosome 22. The two gene segments are fused and ultimately produce a protein that is larger than the normal ABL protein with unregulated tyrosine kinase activity. Consequently, it results in disorders such as chronic myeloid leukemia (CML), Acute Lymphoblastic Leukemia (ALL) and Acute Myelogenous Leukemia (AML).
Technique:
Flourescent in Situ Hybridization
Specialities:
Oncology, Clinical hematology, Medicine
Indications:
Hematological Maligancy
TAT:
3 days
Specimen Requirements:
Bone Marrow/Peripheral Blood in green top (Na-Heparin tube) 3-4 ml
