Reanalysis of Microarray Reports
Microarrays like other new genomic techniques generate vast amounts of data. However, the clinical significance of many of the genes is yet unknown. Newer research and publications across the world are discovering newer associations for various genetic mutations and disorders.
In such a scenario, one may need to review the microarray data over time to corroborate with the latest research and findings. This is especially useful for undiagnosed pediatric cases with normal microarray findings. A wider coverage in the initial testing will allow for greater opportunities for reanalyzing the data. Higher resolution chips are hence preferred to provide for greater coverage of the genome.
Clinical Interpretation of microarray data requires significant skill and experience. Many times the raw data presents several aberrations. These need to be filtered and screened to filter out the noise. The bioinformatics pipelines may reveal or miss out certain changes. The bioinformatics output needs to be evaluated vis-a-vis the published literature and correlate with the clinical findings in order to arrive at a proper judgment about the pathogenicity of the microarray raw data findings.
Should you find your microarray reports confusing, no matter where you got it done, you can send your reports for reanalysis/review or second opinion by our ABMG certified geneticist.
What to expect from Reanalysis
The reanalysis might confirm the findings of the report. Or it might through newer findings which may give you a new direction for your treatment or further testing. It will give more clarity and confidence to your genetic counselor or doctor further guiding you better.
Reach out to us with on firstname.lastname@example.org to learn more about how you can avail reanalysis for microarrays