Aneuploidy 13, 18, 21, X, Y (Prenatal)
Aneuploidy is the most common chromosome abnormality that results in either increase or decrease in the number of chromosomes leading to miscarriage and congenital birth defects.Aneuploidies of five particular chromosomes (13, 18, 21, X, Y) leads to significant percentage of the chromosomal aberrations Therefore, it is highly imperative in prenatal diagnostics to analyze chromosomal abnormalities by utilizing procedures such as Fluorescence In Situ Hybridization or FISH.
In Prenatal Diagnosis, FISH testing is highly useful as one get get early results on common aneuploidies as compared to Karyotyping.
Flourescent in Situ Hybridization
Gynecology, Fetal Medicine, IVF
Abormal Maternal Serum Screening, Ultrasound Abnormalities, Nuchal Translucency, Previous child with genetic abnormality
25-20 ml of Amniotic Fluid OR
15-20mg of CVS tissue in sterile tube with rinse media/normal saline