Double Marker – Two Biochemical Parameters
It has been found that there is a strong correlation between certain biochemical parameters and the fetal abnormalities. Two such biochemical parameters which are relevant in the first trimester are Free Beta-human chorionic gonadotropin (Free B-HCG) and ‘Pregnancy-Associated Plasma Protein (PAAP-A).
By combining the result of the NT Scan and the two biochemical parameters (Dual Maker or Double Marker) into a sophisticated risk calculation algorithm or software, we can provide a reliable indication for the risks of Down Syndrome (Trisomy 21), Edwards Syndrome (Trisomy 18) and Patau Syndromes (Trisomy 13). The First Trimester Screening presents significant advantages over other tests because of higher detection rates (90-95% with 5% false positive rates), and the availability of information at an early stage of pregnancy. ~ (Reference: Fetal Medicine Foundation)