Infertility is a complex condition involving various facets & causes such as physiology, hormones, environment, stress, hereditary, genes and many more. Since genes are the building blocks of any organism, they manage the functioning of various organs & systems including the reproductive system. Hence, genetic studies have an important role in the diagnosis and management of infertility.
Chromosome Analysis
Carriers of balanced chromosomal rearrangements are at an increased risk of infertility, implantation failures, multiple miscarriages, still-births or having a child with a chromosomal abnormality. Screening for balanced translocation in infertile couples can help them in making treatment decisions including donor egg/sperm Or prenatal testing when pregnant because of the increased risk of having congenital anomalies due to unbalanced segregation of the chromosomes in the gametes. Learn More.
Male Infertility
Understanding the genomic quality and content of the sperm can help approach male infertility treatment with greater clarity. In addition to routine andrology assays done at the IVF center, the patient can benefit from genomic assays focused on the Sperm DNA and Y chromosome.
Infectious Disorders
Several infectious disorders such as tuberculosis of the uterus or HPV infection can severely impair the chances of pregnancy. Infertility treatments may yield fewer results until the infectious disorders are first treated or ruled out.
Chromosomal Analysis of Products of Conception
In cases of repeated pregnancy loss, genetic evaluation of the abortus can provide important information to determine the cause of the miscarriage and the likelihood of recurrence. Advanced technologies such as microarray can provide better diagnostic yield in such cases. Learn More.
Carrier Screening
Genetic abnormalities are one of the main causes for children with congenital anomalies or developmental disorders and intellectual disability. Many of these abnormalities occur because one or both parents are a carrier of a mutation. Carrier Screening can help identify the risks a couple may have of passing the mutation to their offspring.
Pre-implantation Genetic Screening & Diagnosis
Pre-implantation Genetic Screening (PGS) can help the IVF center choose a healthier embryo and eliminate the abnormal embryos before implantation. This helps increase the pregnancy outcomes from the IVF process. Pre-implantation Genetic Diagnosis (PGD) on the other hand is useful for identifying or ruling out a specific known genetic abnormality from the embryos.Learn More.