TEL/AML1 t(12;21)-ALL 

Description:

This test is useful in cases of Acute Lymphoblastic Leukemia (ALL) with a suspected TEL/AML translocation. A chimeric product is formed as a result of translocation between the the helix-loop-helix domain of TEL on chromosome 12 fused to AML-1 (RUNX1) gene on chromosome 21, the DNA-binding subunit of the AML-1/CBF beta transcription factor complex. The fused protein formed gives rise to ALL. The test can help in detection of this particular defect using FISH technique. 

Technique:
Flourescent in Situ Hybridization

Specialities:
Oncology, Clinical hematology, Medicine

Indications:
Hematological Maligancy

TAT:
3 days

Specimen Requirements:
Bone Marrow/Peripheral Blood in green top (Na-Heparin tube) 3-4 ml

Test Code:
2212

 

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