ETO/AML t(8;21)-AML-M2

Description:

This test is useful in cases of Acute Myeloid Leukemia (AML) with a suspected AML/ETO translocation. The translocation of the AML1 gene (RUNX1) on chromosome 21 with the ETO gene (RUNX1T1) gene that encodes the CBFA2T1 protein on chromosome 8 forms a fusion protein. The t(8;21) abnormality predisposed to heterogeneous bone marrow malignancy, the Acute myeloid leukemia (AML). The test helps in detection of this translocation leading to AML-M2.

Technique:
Flourescent in Situ Hybridization

Specialities:
AML

Indications:
Hematological Maligancy

TAT:
3 days

Specimen Requirements:
Bone Marrow/Peripheral Blood in green top (Na-Heparin tube) 3-4 ml

Test Code:
2213

 

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