Chromosomal Microarray Analysis – High Resolution Genome Scanning For Precise Diagnosis
Chromosomal Microarray Analysis (CMA) or simply Microarray has become a very popular, useful and powerful tool for genetic analysis.
Chromosomal Microarray Analysis (CMA) or simply Microarray is a whole genome genetic test available to detect a wide range of genetic syndromes, which were previously undetected by traditional technologies. Microarray scans the entire genome at a very high resolution using DNA from the individual, and provides information on thousands of genes in a single test. It can precisely define which genes are missing or extra (See box).
Traditional genetic tests such as standard chromosome studies (Karyotyping) are coarse and cannot provide precise estimate about the chromosomal regions lost or gained in an individual, and cannot exactly define the genomic content of the deletion or duplication.
Unlike Next Generation Sequencing (NGS) which is meant for detection of point mutations and smaller changes in the genome; Chromosomal Microarray Analysis can detect small as well as larger deletions and duplications.
The information from the microarray test provides precise information about the parts of chromosome and the genes involved in any disorder. This test is of enormous practical value to patients and physicians because it provides accurate genetic information, which can be used for improved diagnosis and treatment decisions. Microarray testing is now available for prenatal, paediatric and cancer patients. The Microarray tests are also commonly referred to as Comparative Genomic Hybridization (CGH), Array CGH or CGH Array.
Chromosomal Microarray Analysis (CMA) available through Labassure covers both Copy Number Variations (CNV) as well as Single Nucleotide Polymorphism (SNP). Labassure offers the widest options for Microarray based Genetic Testing.
Microarray tests from Labassure can be ordered from anywhere in India. Our sales team can assist you with regards to the logistics.
Applications in Diagnostics
Chromosomal Micoarray Analysis (CMA) technique provides a very useful handle in diagnosis of ailments related with development delays, autism or any kind of genetic abnormalities. It is highly useful in prenatal diagnosis.
If you are a clinician, geneticist, fetal medicine specialist or researcher interested in microarrays, you can read more about applying microarrays in clinical diagnostics.